![]() 2003 163:265-74.Īsao T, Kuwano H, Ide M, Hirayama I, Nakamura JI, Fujita KI, et al. A systematic review of alternative therapies in the irritable bowel syndrome. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. Liu JH, Chen GH, Yeh HZ, Huang CK, Poon SK. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. ![]() Kline RM, Kline JJ, Di Palma J, Barbero GJ. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Peppermint oil does not relieve the pain of irritable bowel syndrome. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized, double-blind crossover study. Lawson MJ, Knight RE, Tran K, Walker G, Roberts-Thompson A. Sandy, Ore.: Eclectic Medical Publications, 1998. Herb Contraindications and Drug Interactions: With Appendices Addressing Specific Conditions and Medicines. An analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and guinea pig. The mechanism of action of peppermint oil on gastrointestinal smooth muscle. Newton, Mass.: Integrative Medicine Communications, 2000. ![]() Herbal Medicine: Expanded Commission E Monographs. 8 No studies have been done in children younger than eight years.īlumenthal M. 8 After two weeks, 76 percent of patients receiving enteric-coated peppermint reported a reduction in the severity of pain, compared with only 19 percent of control patients. 7 The pediatric study (in children eight to 17 years of age) found a significant reduction in pain but no significant change in other symptoms these findings are particularly important given the lack of effective treatment options for children with IBS. In the adult trial, 79 percent of treated patients experienced a reduction in the severity of abdominal pain, compared with 43 percent of control patients 83 percent had less abdominal distension, compared with 29 percent of control patients 83 percent had reduced stool frequency, compared with 32 percent of control patients and 79 percent experienced less f latulence, compared with 22 percent of control patients ( P <.05). Since the meta-analysis was performed, two additional trials-one in adults (n = 110) 7 and one in a pediatric population (n = 42) 8-have shown a modest but statistically significant benefit. Menthol, which is extracted from peppermint, is a common ingredient in over-the-counter topical products used for respiratory congestion, headache, and muscle pain. Extracts of peppermint are widely used as flavoring (rather than for their medicinal properties) in many products, including toothpastes, mouthwashes, and over-the-counter gastrointestinal (GI) products. Peppermint oil, which is extracted from the stem, leaves, and flowers of the plant, has become popular as a treatment for a variety of conditions, including irritable bowel syndrome (IBS), headache, and non-ulcer dyspepsia ( Table 1). The medicinal use of peppermint and other mint plants probably dates back to the herbal pharmacopoeia of ancient Greece, where peppermint leaf traditionally was used internally as a digestive aid and for management of gallbladder disease it also was used in inhaled form for upper respiratory symptoms and cough. Peppermint (Mentha x piperita) is a perennial flowering member of the mint family, which grows widely in Europe and North America.
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